Product Description

Trajenta 5 mg (Linagliptin)

Uses of trajenta 5 mg tablet (Linagliptin)

Trajenta 5 mg tablet is used alone or in combination with other drugs to treat type 2 diabetes mellitus.

How Dose trajenta 5 mg tablet (Linagliptin) works

trajenta 5 mg tablet is an oral antidiabetic belongs to a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It acts by inhibiting the enzyme (dipeptidyl peptidase-4; DPP-4) which prevents the breakdown of substances called as incretins, ultimately increasing the production of insulin that reduces blood glucose level at fasting and after intake of food.

What is linagliptin?

Linagliptin is an oral diabetes medicine that helps control blood sugar levels. It works by regulating the levels of insulin your body produces after eating. It is used together with diet and exercise to treat type 2 diabetes. It is not for treating type 1 diabetes. It may also be used for purposes not listed in this medication guide.

What is the most important information I should know about linagliptin?

Do not use this medicine if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Linagliptin is not for treating type 1 diabetes.

What should I discuss with my healthcare provider before taking linagliptin?

You should not use this medicine if you are allergic to linagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

To make sure linagliptin is safe for you, tell your doctor if you have:

• pancreatitis;
• high triglycerides (a type of fat in the blood);
• gallstones;
• a history of alcoholism; or
• if you are using insulin, or taking other oral diabetes medication.

Linagliptin is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether linagliptin passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

This medicine is not approved for use by anyone younger than 18 years old.

How should I take linagliptin?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

You may take this medicine with or without food. Follow your doctor’s instructions.

Your blood sugar will need to be checked often, and you may need other blood tests at your doctor’s office.

Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. Symptoms include headache, hunger, sweating, pale skin, irritability, dizziness, feeling shaky, or trouble concentrating. Always keep a source of sugar with you in case you have low blood sugar.

Sugar sources include fruit juice, hard candy, crackers, raisins, and non-diet soda. Be sure your family and close friends know how to help you in an emergency.

If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Your doctor can prescribe a glucagon emergency injection kit and tell you how to use it.

Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor’s advice.

Linagliptin is only part of a treatment program that may also include diet, exercise, weight control, blood sugar testing, and special medical care. Follow your doctor’s instructions very closely.

Store at room temperature away from moisture and heat. click more: trajenta 5 mg tablet

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention, Just in case if you’re taking an additional dose, consult your doctor and do as instructed.

What should I avoid while taking linagliptin?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity.

Common side effects

Pancreatic inflammation, Angioedema (swelling of deeper layers of skin), Urticaria, Constipation, Cough, Fall in blood sugar level, Rash

Tablet contains Linagliptin which is an oral anti-diabetic agent. It is used to treat type 2 diabetes mellitus in adults when treatment with first line oral anti-diabetic medicine (such as metformin) or diet and exercise does not give adequate response.

It is generally used in combination with other anti-diabetic medicines (such as metformin, glimepiride, glipizide, empagliflozin, or insulin) for better results.

Type 2 diabetes is a chronic medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms includes excessive urination, excessive thirst, hunger, fatigue, and blurred vision.

trajenta 5 mg tablet may be taken with or without food. Avoid taking more than the prescribed dose as it may increase the risk of side effects.

Avoid the discontinuation of trajenta 5 mg tablet without consulting your doctor, as it may cause an increase in blood sugar levels. It may also increase the risk of other diabetes-related complications.

Your doctor may suggest that you monitor your blood sugar levels regularly to ensure that your diabetes is under control. Also, do regular follow-up visits so that your doctor can evaluate your condition.

Maintain a proper diet and do regular exercise to get maximum benefits of the treatment.

Disease interactions

Pancreatitis
Pancreatitis is the swelling of the pancreas, a gland that produces chemical substances which help in digestion and regulation of blood sugar. Trajenta 5 mg Tablet may increase the risk of pancreatitis and should be used with caution if you have a history of acute pancreatitis. Consult your doctor before taking this medicine.

Diabetic Ketoacidosis
Diabetic ketoacidosis is a complication of diabetes that causes high amounts of acids in your blood. Trajenta 5 mg Tablet is not recommended for use if you have diabetic ketoacidosis as it may worsen your condition.

Food interactions
Information not available.

Lab interactions
Information not available.
This is not an exhaustive list of possible drug interactions. You should consult your doctor about all the possible interactions of the drugs you’re taking.

Expert advice for trajenta 5 mg tablet

Do not start or continue linagliptin and consult your doctor:

• If you are allergic to linagliptin or to any medicine from the same group (DPP-4 inhibitors).
• If you have type 1 diabetes or if you have serious complication of diabetes where high levels of blood acids called ketones are produced in your body (diabetic ketoacidosis).
• If you are taking insulin or other antidiabetic drug known as a sulphonylurea, your doctor may reduce the dose of your medicines, as it may otherwise cause excessively low blood glucose (hypoglycemia).
• If you are already being treated with insulin (medicine to lower blood sugar levels) and have severe kidney disease.
• If you have/had a disease of the pancreas.
• Do not substitute it with insulin, if you are on insulin.

Miscelleneous

Can be taken with or without food, as advised by your doctor
To be taken as instructed by doctor
Does not cause sleepiness

How it works

Trajenta 5 mg Tablet works by increasing the release of insulin (a chemical substance that helps regulate blood sugar levels) into the blood, thus helping to decrease blood sugar levels.
It also increases the activity of a hormone (Glucagon-like peptide-1), which helps to control blood sugar levels.

Frequently asked questions for trajenta 5 mg tablet

Q. Is linagliptin better than sitagliptin?

Linagliptin and sitagliptin belong to same class of drugs (DPP-4 inhibitor) with similar action, but their effect may vary upon individual response.

Q. Is linagliptin available in India?

Yes, linagliptin is available in India with brand name as trajenta 5 mg tablet.

Q. Is linagliptin generic?

Linagliptin is generic name; however, linagliptin is not available in a generic form.

Q. Is linagliptin safe?

Linagliptin is safe if used at prescribed doses for the prescribed duration as advised by your doctor.

Q. How is linagliptin excreted?

Linagliptin is mainly excreted in stools and less in urine.

Q. What is linagliptin and for which treatment used for?

Linagliptin belongs to a group of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors, and used in addition to diet and exercise for the treatment of type-2 diabetes.

From Where I can Buy trajenta 5 mg tablet?

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What is the use of TRAJENTA 5MG?

TRAJENTA 5MG is used to treat type 2 diabetes mellitus in adults, it is a condition in which the body does not make enough insulin or the insulin produced does not work properly. While taking this medicine follow proper diet regimen and exercise schedule to reduce high blood sugar levels.

Does TRAJENTA 5MG cause hypoglycaemia (low blood sugar)?

When TRAJENTA 5MG taken in combination with medicines called sulphonylureas and/or insulin, it can cause decrease in your blood sugar levels which may affect your consciousness.

Your doctor may recommend frequent blood test to monitor your glucose level to minimise the risk of hypoglycaemia, especially combined with sulphonylurea and/or insulin.

How does TRAJENTA 5MG works?

TRAJENTA 5MG increases the release of insulin from the pancreas and thus decreases the hormones that raise blood sugar levels. This reduces the fasting and post meal sugar level.

Is TRAJENTA 5MG safe to use in kidney disease patients?

Yes, TRAJENTA 5MG is safe to use in patients with kidney disease and no dose adjustment is recommended for these patients.

REFERENCES
1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. seventh edition.2013. Page-275

2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page 2247-2248.

3. Rachael Aletti 1, Angela Cheng-Lai. Linagliptin: the newest dipeptidyl peptidase-4 inhibitor for type 2 diabetes mellitus. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jan-Feb 2012. [Accessed 24th March 2022] https://pubmed.ncbi.nlm.nih.gov/22143285/

4. Boehringer Ingelheim Pharma GmbH & Co. KG; Electronic Medicines Compendium (EMC) [Revised on June2020] [Accessed 24th March 2022] https://www.medicines.org.uk/emc/files/pil.4762.pdf

5. Boehringer Ingelheim Pharmaceuticals, Inc 2011; U.S. Food & Drug Administration; [Revised on may2011] [Accessed 24th March 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/201280lbl.pdf