Topirol 50mg Tablet


Topirol 50mg Tablet 10’S


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Topirol 50

TOPIROL 50MG contains Topiramate which belongs to a group of medicines called anti-epileptic medicines. It is used to treat seizures in both adults as well as in children. It can also be used to prevent migraine headaches in adults. A seizure is a sudden, uncontrollable electrical changes or disturbance in your brain.

It may cause changes in behavior, movements or feelings and in levels of consciousness. Topiramate prevents the occurrence of seizures and prevents migraine symptoms by reducing neural pathway excitability.

You might shed your weight if you use topiramate continuously. If you are losing too much weight, you should consult your doctor. You can take topiramate with or without food. Drink plenty of fluids during the day to prevent kidney stones while taking topiramate tablets. You should avoid drinking alcohol when taking topiramate tablet.

This medicine can harm an unborn baby. So, it is not recommended for use in pregnant women. Mothers who breastfeed while taking TOPIROL 50MG, must tell the doctor as soon as possible if the baby experiences anything unusual.

Topirol 50 Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).

Topirol 50 Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better.

Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.

Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter.

You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.


Treat seizures in adults and children
Prevent migraine headaches in adults


Topiramate stimulates GABA-A receptor activity at brain, a non-benzodiazepine receptor sites and reduces glutamate activity at both AMPA and kinate receptors. By increasing GABA activity and inhibiting glutamate activity, topiramate blocks neuronal excitability, preventing seizures and migraine.


Always take this medicine as directed by your physician. It can be taken before, during, or after a meal. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the dose and duration of the therapy depending upon your age, weight and condition. To prevent kidney stones, drink plenty of fluids during the day.


In Epilepsy/Seizures

Topirol 50 Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures.
By controlling the frequency of seizures, it will help you go about your daily activities with more confidence. It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

In Prevention of Migraine

It is not fully established how Topirol 50 Tablet helps prevent migraines. It may change the abnormal and excessive activity of the nerve cells in the brain or increase the activity in a region of the brain associated with migraines.
By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

In Lennox–Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures. Topirol 50 Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.



• Depression (new or worse)
• Seizures (fits)
• Anxiety, irritability, changes in mood, confusion, disorientation
• Problems with concentration, thinking and memory
• Kidney stone, frequent or painful urination
• Increased acid level in the blood (shortness of breath, loss of appetite, nausea, vomiting, excessive tiredness, and fast or uneven heart beats)
• Having thoughts of serious self-harm
• Glaucoma or inflammation in the eye


• Weight loss
• Anemia
• Dizziness
• Nausea or vomiting
• Diarrhea, constipation, bloating, abdominal pain
• Allergic reaction such as skin redness, rash, itching, facial swelling, hives
• Difficulty in sleeping
• Slurred speech, blurred vision, vertigo, ringing in the ears
• Lack of coordination when walking
• Impaired sense of taste and touch
• Hair loss
• Joint pain, muscle pain, chest pain
• Psychosis (severe mental disorder)
• Slow or irregular heartbeat, low blood pressure,
• Pancreatitis (inflammation of the pancreas)
• Learning disability


• Loss of consciousness
• Night blindness
• Abnormal skin odour


Nausea or vomiting:

Try taking this medicine with, or just after, a meal. Stick to simple meals. Do not eat rich or spicy food.


Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.


Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.


Talk to your doctor, if you are taking,

Birth control pills
Other medicines used to treat epilepsy (e.g. carbamazepine or phenytoin)
Medicines used to treat depression (e.g. risperidone, lithium, amitriptyline, venlafaxine, St John?s Wort)
Warfarin (used to thin the blood)
Medicines used to treat angina and high blood pressure (e.g. hydrochlorothiazide, propranolol or diltiazem)
Medicines used to treat diabetes (e.g. metformin, pioglitazone, glibenclamide)
Flunarazine (used to treat migraine)
Digoxin (used for heart problems)
Haloperidol (used for mental health problems)
Proguanil (used to treat malaria)
Omeprazole (used to treat stomach acid)


Drug : Topiramate
Pharmacological Category : Anticonvulsant
Therapeutic Indication : Epilepsy, Prophylaxis of migraine headache
Dosage Forms : Tablet


Store below 20-25°C and keep out of reach of children.

Q: Can TOPIROL 50MG cause weight loss?
A: Yes. You might shed your weight if you use topiramate continuously. If you are losing too much weight, you should consult your doctor.

Q: Is TOPIROL 50MG habit-forming?
A: No. This medicine is not habit-forming.




It is unsafe to consume alcohol with Topirol 50 Tablet.


Topirol 50 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

Topirol 50 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.


Topirol 50 Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.


Topirol 50 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Topirol 50 Tablet may be needed. Please consult your doctor.


Topirol 50 Tablet should be used with caution in patients with liver disease. Dose adjustment of Topirol 50 Tablet may be needed. Please consult your doctor.


Q. For how long do I need to take Topirol 50 Tablet?

The dose and duration of this medicine will depend on your doctor’s advice. Topirol 50 Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.

Q. Is Topirol 50 Tablet good for anxiety?

Topirol 50 Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.

Q. What are the serious side effects of Topirol 50 Tablet?

Serious side effects of Topirol 50 Tablet are rare. The serious effects of Topirol 50 Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat).
Other serious side effects of Topirol 50 Tablet could be suicidal thoughts and insufficient sweating (some children taking Topirol 50 Tablet may not sweat enough in hot weather, causing their body temperatures to rise).

Q. I am taking valproic acid for fits. Will Topirol 50 Tablet interfere with the working of valproic acid? Can this combination be taken?

Topirol 50 Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems.
It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, Topirol 50 Tablet alone can cause hyperammonemia.

Q. Can Topirol 50 Tablet be used in children?

Yes, Topirol 50 Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.

Q. Since I have started using Topirol 50 Tablet people are saying that I have lost weight. Is it because of Topirol 50 Tablet or something else for which I should get investigated?

It could be due to Topirol 50 Tablet because Topirol 50 Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.


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