Topaz 100mg Tablet


Topaz 100mg Tablet 15’S


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TOPAZ 100MG contains Topiramate which belongs to the group of medicines called antiepileptics

Topaz 100 Tablet is a medicine used to treat epilepsy (seizures) and to prevent migraines. It is also used in the treatment of Lennox-Gastaut syndrome (a rare, but severe form of epilepsy that starts in early childhood).

Tablet may be taken with or without food, preferably at the same time, each day. If you have missed a dose, take it as soon as you remember it and finish the full course of treatment even if you feel better.

Stopping the medication suddenly without talking to your doctor may cause an increased frequency of seizures. Your doctor may advise regular monitoring of serum bicarbonate levels while you are taking this medicine.

Some of the common side effects of this medicine include nausea, taste change, fatigue, diarrhea, weight loss, loss of appetite, and memory impairment. It may also cause vision problems like myopia or glaucoma, so it is important to get your eyesight checked before you start the treatment and regularly thereafter.

You may experience dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Please consult your doctor if these side effects bother you or do not go away.

What is used for?

It is used,

To treat certain types of seizures and generalized tonic- clonic seizures

In combination with other medicines to treat certain types of seizures (partial onset seizures, primary generalized tonic-clonic seizures and seizures associated with Lennox-Gastaut syndrome)

To prevent migraine headaches

Talk to Doctor

Talk to your doctor before taking this medicine, if you:

Have or have had depression, mood problems or suicidal thoughts or behavior

Have kidney problems, have kidney stones, or are getting kidney dialysis

Have a history of metabolic acidosis (too much acid in the blood)

Have liver problems

Have weak, brittle or soft bones (osteomalacia, osteoporosis, osteopenia, or decreased bone density)

Have lung or breathing problems

Have eye problems, especially glaucoma

Have diarrhoea

Have a growth problem

Are on a diet high in fat and low in carbohydrates, which is called a ketogenic diet

Are having surgery

Pregnancy & Breast Feeding

Talk to your doctor before taking this medicine if you are pregnant or breast feeding

Children & Adolescents

Consult your doctor for the use of TOPAZ 100MG in children and adolescents


Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Especially tell your healthcare provider if you take:

Valproic acid

Any medicines that impair or decrease your thinking, concentration or muscle coordination

Birth control pills


In Epilepsy/Seizures

Tablet is an anticonvulsant (or anti-epileptic) medicine that works by decreasing the nerve impulses which cause the seizures. By controlling the frequency of seizures, it will help you go about your daily activities with more confidence.
It helps reduce symptoms such as confusion, uncontrollable jerking movements, loss of awareness, and fear or anxiety.
This medicine is not associated with any physical or psychological dependence (addiction) but it should not be stopped suddenly. It must be taken regularly as prescribed to be effective. Missing doses may trigger a seizure.

In Prevention of Migraine

It is not fully established how Tablet helps prevent migraines. It may change the abnormal and excessive activity of the nerve cells in the brain or increase the activity in a region of the brain associated with migraines.
By preventing and reducing the frequency of headaches, it can help you carry out your daily activities and have a better quality of life.

In Lennox–Gastaut syndrome

Lennox-Gastaut syndrome (LGS) is a rare but severe form of epilepsy that usually starts in early childhood. Affected children may experience several different types of seizures.
Tablet helps prevent and control these seizures by decreasing the nerve impulses which cause the seizures.

Directions & For Use

Take TOPAZ 100MG exactly as prescribed by your doctor

Your healthcare provider may change your dose. Do not change your dose without talking to your healthcare provider

It should be swallowed whole. Do not chew the tablet. They may leave a bitter taste

This medicine can be taken before, during, or after a meal. Drink plenty of fluids during the day This may help prevent kidney stones while taking TOPAZ 100MG

Do not drink alcohol while taking this medicine

If you take too much TOPAZ 100MG

If you take too much TOPAZ 100MG, call your healthcare provider and go to the nearest emergency room

If you miss a single dose of TOPAZ 100MG

Take it as soon as you can. Do not double your dose

If you stop taking TOPAZ 100MG

Do not stop taking TOPAZ 100MG without talking to your healthcare provider. Stopping this medicine suddenly may cause serious problems


Like all medicines, this medicine can cause side effects, although not everybody gets them.

High blood ammonia levels such as affect your mental activities, slow your alertness, make you feel tired or cause vomiting

Kidney stones

Low body temperature

Effects on thinking and alertness such as affect how you think and cause confusion, problems with concentration, attention, memory or speech


Store at room temperature (15-25?C)

Keep TOPAZ 100MG in a tightly closed container

Keep out of reach of children

In-Depth Precautions and Warning

Drug Warnings

Topaz 100 Tablet 10’s may cause a congenital disability called cleft lip in unborn baby, so the use of this medicine is not allowed in pregnant females. Tablet 10’s may increase the body temperature and reduce sweating, so one should report it to the doctor if they are noticing decreased sweating and hot, dry skin.

tablet 10’s may enhance the level of acid in the blood so one should tell their doctor if they have irregular heartbeats or loss of hunger. Before taking Topaz 100 Tablet 10’s, tell the doctor if you have diarrhoea, metabolic acidosis, eye problems, liver disease.

Topaz 100 Tablet 10’s may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. So, one should tell their doctor if they are using any contraceptives to prevent pregnancy.

Drug Interactions

Drug-Drug Interaction: A person should tell the doctor about all the medications they are using, including the medicines used to treat diabetes (metformin, glibenclamide, pioglitazone), medicines used to treat depression or anxiety  (venlafaxine, amitriptyline), medicines for heart or blood pressure (diltiazem, hydrochlorothiazide, propranolol), antipsychotic medicines (risperidone), and or any other epilepsy medicines.

Drug-Food Interaction: The use of alcohol with Tablet 10’s is restricted as alcohol may worsen the side effects of the medicine.

Drug-Disease Interaction: The use of Tablet 10’s is restricted in patients dealing with bone marrow depression/blood dyscrasias, hyperthermia, severe liver disease, suicidal tendency, renal dysfunction, metabolic acidosis, angle-closure glaucoma, hemodialysis, and nephrolithiasis




It is unsafe to consume alcohol with Tablet.


Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

Breast feeding

Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.


Tablet may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.


Topaz 100 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Tablet may be needed. Please consult your doctor.


Topaz 100 Tablet should be used with caution in patients with liver disease. Dose adjustment of Tablet may be needed. Please consult your doctor.


Q. For how long do I need to take Topaz 100 Tablet?

The dose and duration of this medicine will depend on your doctor’s advice. Topaz 100 Tablet does not cure your condition (seizures/migraine) but prevents them from occurring. So, you may have to keep taking it for months or years depending on improvement in your symptoms and side effects that may occur.

Q. Is Topaz 100 Tablet good for anxiety?

Topaz 100 Tablet is not indicated for the treatment of anxiety. Please consult your doctor before taking the medicine.

Q. What are the serious side effects of Topaz 100 Tablet?

Serious side effects of Topaz 100 Tablet are rare. The serious effects of Topaz 100 Tablet may include glaucoma (difficulty in seeing, eye pain, and blurred vision), kidney stones (sharp pain in your sides or lower back), and metabolic acidosis (tiredness, loss of appetite, irregular and faint heartbeat).
Other serious side effects of Topaz 100 Tablet could be suicidal thoughts and insufficient sweating (some children taking Topaz 100 Tablet may not sweat enough in hot weather, causing their body temperatures to rise).

Q. I am taking valproic acid for fits. Will Topaz 100 Tablet interfere with the working of valproic acid? Can this combination be taken?

Topaz 100 Tablet does not interfere with the working of valproic acid, but it increases the risk of getting excess levels of ammonia in the blood (hyperammonemia). Increased levels of ammonia in the blood can be dangerous and may cause difficulty in thinking, remembering information, or solving problems.
It may also decrease your alertness and make you feel very sleepy with low energy. Immediately inform your doctor if you notice these symptoms. It is important to know that, in rare cases, Topaz 100 Tablet alone can cause hyperammonemia.

Q. Can Topaz 100 Tablet be used in children?

Yes, Topaz 100 Tablet is used for seizures in children more than 2 years of age. However, because of the lack of any reports, this medicine is not recommended to be used in children for migraines.

Q. Since I have started using Topaz 100 Tablet people are saying that I have lost weight. Is it because of Topaz 100 Tablet or something else for which I should get investigated?

It could be due to Topaz 100 Tablet because Topaz 100 Tablet commonly causes weight loss probably due to a decrease in appetite. If you still have any doubts, talk to your doctor who will advise you appropriately.


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