FOLITRAX 25MG contains methotrexate which belongs to a group of medicine called anti-metabolites. It works by stopping or slowing the growth of cancer cells. It can also be used as an immunosuppressant, which reduces the activity of the immune system. In larger doses, it can be used to treat various forms of cancer. In smaller doses, it can be used to treat severe form of psoriasis (a skin disease with thickened patches of inflamed red skin, often covered by silvery scales) and rheumatoid arthritis, when it has not responded to other treatments.
Methotrexate kills the rapidly multiplying cells of the skin in psoriasis. In rheumatoid arthritis, it reduces inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division. FOLITRAX 25MG must not be given to pregnant or breastfeeding women.
Consult your doctor before taking. Before taking this medicine, inform your doctor if you have kidney or liver problems, anemia or weak immune system. click here : Folitrax 25
USES OF FOLITRAX 25MG:
Treats various forms of cancer such as choriocarcinoma, Non-Hodgkin’s lymphoma, breast cancer, acute lymphoblastic leukemia, head and neck cancer, gastric cancer, osteogenic sarcoma, bladder cancer, Burkitt’s lymphoma or advanced stages of childhood lymphoma
Used in severe form of psoriasis
Treats rheumatoid arthritis
HOW FOLITRAX 25MG WORKS:
Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.
Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues. Methotrexate has an immunosuppressive effect, resulting in the inhibition of lymphocyte multiplication. In psoriasis, it kills the rapidly multiplying skin cells.
DIRECTIONS FOR USE:
This medicine should be only given by a doctor or a nurse into a vein (intravenously), muscle (intramuscularly) or into an artery (intraarterially). It may also be given by an infusion (drip) into a vein. Your doctor will decide the correct dose for you and how often it must be given.
SIDE EFFECTS OF FOLITRAX 25MG:
Allergic reaction (a sudden itchy rash, swelling of hands, feet, ankles, face, lips, mouth or throat which may cause difficulty in swallowing or breathing)
Spitting or coughing blood
Symptoms of an infection e.g. fever, chills, achiness, sore throat
Black tarry stools
A sore mouth
Feeling or being sick
Dizziness or drowsiness
Vasculitis (pain or redness of blood vessels)
Jaundice (yellowing of skin and whites of eyes)
Cystitis (painful urination)
Blurred vision or eye infection (conjunctivitis)
Pain in stomach, loins or abdomen
Irregular periods in women
Ringing of the ears
Joint and muscle pain
Inflammation of the lungs
Shingles (Herpes Zoster)
HOW TO MANAGE SIDE EFFECTS:
Feeling sick or being sick:
Try taking this medicine with, or just after, a meal and stick to simple meals. Do not eat rich or spicy food.
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
Talk to your doctor, if you are taking,
Medicines used to relieve pain (e.g. ibuprofen, aspirin or similar medicines)
Medicines used to reduce the acid production (e.g. omeprazole, esomeprazole and pantoprazole)
Diuretics (water tablets)
Medicines used to treat diabetes (insulin)
Antibiotics (used to treat infection) such as penicillins, sulphonamides, co-trimoxazole, trimethoprim, tetracycline, chloramphenicol and para-aminobenzoic acid
Phenytoin (used to treat epilepsy)
Vitamin supplements containing folic acid
Probenecid (medicine used to treat gout)
Nitrous oxide (used for general anaesthesia and pain relief)
Retinoids, such as acitretin (a medicine used to treat psoriasis) or isotretinoin (used to treat severe acne)
Live virus vaccines
Mercaptopurine (medicine used to treat blood cell cancer)
Theophylline (medicine used to treat asthma)
Drug : Methotrexate
Pharmacological Category : Antimetabolite, Antirheumatic, Immunosuppressant Agent
Therapeutic Indication : Psoriasis, Rheumatoid arthritis, Cancer
Dosage Forms : Tablet, Injection, Gel
Store below 20-25°C and keep out of reach of children.
FAQ’s ABOUT FOLITRAX 25MG:
Q: Can FOLITRAX 25MG be given to pregnant women?
A: No. This medicine can cause birth defects, harm the unborn child or cause miscarriage. So, it should not be given to pregnant women unless necessary.
Q: Can FOLITRAX 25MG be given to children?
A: Yes. This medicine should be used with caution in children. Special care is required.
Folitrax 25 Injection is given under the supervision of a healthcare professional and should not be self-administered.It may be used by itself or in combination with other medicines. Your doctor will decide what dose is necessary and how often you need to take it.
This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.
Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
You should avoid drinking alcohol as it may increase your risk of liver damage.
most common side effects
If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.It is powerful medicine, and some people may develop serious side effects while taking it.
This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you on regular blood tests to check for these.
Before taking it, tell your doctor if you are pregnant, have stomach, liver, or kidney problems, or are taking any medicines to treat infections.
Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding.
It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine.
USES OF FOLITRAX INJECTION
- Treatment of Rheumatoid arthritis
- Treatment of Psoriasis
BENEFITS OF FOLITRAX INJECTION
In Treatment of Rheumatoid arthritis
Folitrax 25 Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment.
It works by reducing the body’s immune system, this decreases swelling, reduces pain, stiffness, and improves function.
Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.
In Treatment of Psoriasis
Folitrax 25 Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly.
Folitrax 25 Injection works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit.
DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.
SIDE EFFECTS OF FOLITRAX INJECTION
Common side effects of Folitrax
- Abdominal pain
- Loss of appetite
- Mouth sore
HOW TO USE FOLITRAX INJECTION
HOW FOLITRAX INJECTION WORKS
Regular monitoring of kidney function test is advised while you are taking this medicine.
Use of Folitrax 25 Injection is not recommended in patients with severe liver disease.