Folitrax 25 mg Injection 1ml


Folitrax 25mg Injection 1ml


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Folitrax 25

FOLITRAX 25MG contains methotrexate which belongs to a group of medicine called anti-metabolites. It works by stopping or slowing the growth of cancer cells. It can also be used as an immunosuppressant, which reduces the activity of the immune system. In larger doses, it can be used to treat various forms of cancer. In smaller doses, it can be used to treat severe form of psoriasis (a skin disease with thickened patches of inflamed red skin, often covered by silvery scales) and rheumatoid arthritis, when it has not responded to other treatments.

Methotrexate kills the rapidly multiplying cells of the skin in psoriasis. In rheumatoid arthritis, it reduces inflammation in joints by altering body’s defence mechanism in immune system. In cancer, methotrexate inhibits the enzymes responsible for nucleotide synthesis and prevents cell division. FOLITRAX 25MG must not be given to pregnant or breastfeeding women.
Consult your doctor before taking. Before taking this medicine, inform  your doctor if you have kidney or liver problems, anemia or weak immune system. click here : Folitrax 25


Treats various forms of cancer such as choriocarcinoma, Non-Hodgkin’s lymphoma, breast cancer, acute lymphoblastic leukemia, head and neck cancer, gastric cancer, osteogenic sarcoma, bladder cancer, Burkitt’s lymphoma or advanced stages of childhood lymphoma
Used in severe form of psoriasis
Treats rheumatoid arthritis


Methotrexate inhibits the enzymes responsible for nucleotide synthesis including dihydrofolate reductase, thymidylate synthase, aminoimidazole caboxamide ribonucleotide transformylase (AICART) and amido phosphoribosyl transferase which prevents cell division and leads to anti-inflammatory actions.

Since cellular proliferation in malignant tissues (cancerous tissue) are greater than in most normal tissues, methotrexate may impair malignant growth without causing any irreversible damage to normal tissues. Methotrexate has an immunosuppressive effect, resulting in the inhibition of lymphocyte multiplication. In psoriasis, it kills the rapidly multiplying skin cells.


This medicine should be only given by a doctor or a nurse into a vein (intravenously), muscle (intramuscularly) or into an artery (intraarterially). It may also be given by an infusion (drip) into a vein. Your doctor will decide the correct dose for you and how often it must be given.



• Allergic reaction (a sudden itchy rash, swelling of hands, feet, ankles, face, lips, mouth or throat which may cause difficulty in swallowing or breathing)
• Spitting or coughing blood
• Symptoms of an infection e.g. fever, chills, achiness, sore throat
• Black tarry stools
• A sore mouth
• Diarrhea
• Stroke
• Chest pain


• Feeling or being sick
• Dizziness or drowsiness
• Fits
• Vasculitis (pain or redness of blood vessels)
• Jaundice (yellowing of skin and whites of eyes)
• Cystitis (painful urination)
• Headaches
• Blurred vision or eye infection (conjunctivitis)
• Osteoporosis
• Pain in stomach, loins or abdomen
• Irregular periods in women
• Hair loss
• Ringing of the ears
• Joint and muscle pain
• Mood alterations
• Inflammation of the lungs
• Shingles (Herpes Zoster)


Feeling sick or being sick:

Try taking this medicine with, or just after, a meal and stick to simple meals. Do not eat rich or spicy food.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.


Talk to your doctor, if you are taking,

Medicines used to relieve pain (e.g. ibuprofen, aspirin or similar medicines)
Medicines used to reduce the acid production (e.g. omeprazole, esomeprazole and pantoprazole)
Diuretics (water tablets)
Medicines used to treat diabetes (insulin)
Antibiotics (used to treat infection) such as penicillins, sulphonamides, co-trimoxazole, trimethoprim, tetracycline, chloramphenicol and para-aminobenzoic acid
Phenytoin (used to treat epilepsy)
Vitamin supplements containing folic acid
Probenecid (medicine used to treat gout)
Nitrous oxide (used for general anaesthesia and pain relief)
Retinoids, such as acitretin (a medicine used to treat psoriasis) or isotretinoin (used to treat severe acne)
Live virus vaccines
Mercaptopurine (medicine used to treat blood cell cancer)
Theophylline (medicine used to treat asthma)


Drug : Methotrexate
Pharmacological Category : Antimetabolite, Antirheumatic, Immunosuppressant Agent
Therapeutic Indication : Psoriasis, Rheumatoid arthritis, Cancer
Dosage Forms : Tablet, Injection, Gel


Store below 20-25°C and keep out of reach of children.


Q: Can FOLITRAX 25MG be given to pregnant women?
A: No. This medicine can cause birth defects, harm the unborn child or cause miscarriage. So, it should not be given to pregnant women unless necessary.

Q: Can FOLITRAX 25MG be given to children?
A: Yes. This medicine should be used with caution in children. Special care is required.


Folitrax 25 Injection is a medicine used to treat rheumatoid arthritis where it helps prevent further joint damage. It is also used to treat severe forms of a skin disease called psoriasis and tumors in a range of cancers. For psoriasis, it works by killing the cells in the skin that grow too quickly.
Folitrax 25mg Injection 1ml
Folitrax 25 Injection is given under the supervision of a healthcare professional and should not be self-administered.It may be used by itself or in combination with other medicines. Your doctor will decide what dose is necessary and how often you need to take it.

This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised.

Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to.
You should avoid drinking alcohol as it may increase your risk of liver damage.

most common side effects

The most common side effects of this medicine include nausea, vomiting, loss of appetite, indigestion, abdominal pain, increased liver enzymes, and stomatitis (inflammation of the mouth). Your doctor may advise you to take folic acid to reduce some of these.
If they do not go away or get worse, tell your doctor. There may be ways of preventing or reducing these effects.It is powerful medicine, and some people may develop serious side effects while taking it.

This medicine may lower your ability to fight infections and lead to problems with your blood, liver, or kidneys. Your doctor will advise you on regular blood tests to check for these.

Before taking it, tell your doctor if you are pregnant, have stomach, liver, or kidney problems, or are taking any medicines to treat infections.

Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding.

It may harm your baby. You and your partner should avoid becoming pregnant or fathering a child for several months after your treatment with it has stopped. Your doctor may perform several tests such as blood tests, X-rays, and physical examinations both before and during treatment with this medicine.


  • Treatment of Rheumatoid arthritis
  • Treatment of Psoriasis


In Treatment of Rheumatoid arthritis

Folitrax 25 Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe rheumatoid arthritis if other treatments have already been tried and have not worked. It is not a first-line treatment.

It works by reducing the body’s immune system, this decreases swelling, reduces pain, stiffness, and improves function.

Take it exactly as prescribed and for as long as it is prescribed to get the most benefit. Do not take more than you should. It may take several months to become fully effective.

In Treatment of Psoriasis

Folitrax 25 Injection belongs to a group of medicines called antimetabolites. It may be used to treat severe psoriasis when other treatments have not worked. Psoriasis is a condition where the skin cells in the body grow too quickly.

Folitrax 25 Injection works by killing these fast-growing cells. It is potent and very toxic medicine and you should discuss the risks and benefits with your doctor. Take it exactly as prescribed and for as long as it is prescribed to get the most benefit.

DO NOT take more than you should. It may take several months to become fully effective. You should avoid drinking alcohol while having this treatment and drink plenty of water to stay hydrated.


Most side effects do not require any medical attention and disappear as your body adjusts to the medicine. Consult your doctor if they persist or if you’re worried about them

Common side effects of Folitrax

  • Abdominal pain
  • Indigestion
  • Loss of appetite
  • Nausea
  • Vomiting
  • Tiredness
  • Mouth sore


Your doctor or nurse will give you this medicine. Kindly do not self administer.


Folitrax 25 Injection is an immunosuppressant. In rheumatoid arthritis, it works by decreasing the activity of the body’s immune system. This decreases swelling, reduces pain and stiffness, and improves function. In psoriasis, it works by slowing down the rapid growth of skin cells.




Caution is advised when consuming alcohol with Folitrax 25 Injection. Please consult your doctor.


Folitrax 25 Injection is highly unsafe to use during pregnancy. Seek your doctor’s advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

Breast feeding

Folitrax 25 Injection is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.


Folitrax 25 Injection may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.


Folitrax 25 Injection should be used with caution in patients with kidney disease. Dose adjustment of Folitrax 25 Injection may be needed. Please consult your doctor.
Regular monitoring of kidney function test is advised while you are taking this medicine.


Folitrax 25 Injection should be used with caution in patients with liver disease. Dose adjustment of Folitrax 25 Injection may be needed. Please consult your doctor.
Use of Folitrax 25 Injection is not recommended in patients with severe liver disease.


Q. Can Folitrax 25 Injection cause mouth ulcers?

Yes, Folitrax 25 Injection can cause a sore mouth and mouth ulcers as side effects in some cases. Taking folic acid along with this medicine may help in reducing the ulcers. Ask your doctor if the dose can be reduced as dose reduction may further help in reducing the ulcers.

Q. Why do I have to take folic acid with Folitrax 25 Injection?

Folic acid is required to make new cells in the body and Folitrax 25 Injection decreases the folic acid levels in the body. Folic acid can help reduce some of the common side effects of Folitrax 25 Injection such as mouth ulcers, hair loss, nausea, heartburn, abdominal pain, fatigue, anemia and liver problems.

Q. Why do I need to take regular blood tests while taking Folitrax 25 Injection?

Regular blood tests will help your doctor to check your response to Folitrax 25 Injection and monitor you for side effects. You will need to regularly check your liver function and your blood counts (white blood cells, red blood cells and platelets). Your doctor may also order additional tests depending on the results.


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