What is Janumet Tablet?
Janumet 50 mg/500 mg Tablet is a combination of two medicines that control high blood sugar levels in people with type 2 diabetes mellitus. This helps prevent serious complications of diabetes such as kidney damage and blindness and may reduce your chances of having a heart attack or stroke.
Janumet 50 mg/500 mg Tablet may be prescribed alone or along with other diabetes medications. It works best when used along with a healthy diet and regular exercise. The dose you are given will depend on your condition, blood sugar levels, and what other medicines you are taking. Taking it with meals helps to reduce the chances of developing an upset stomach.
You should take it regularly, at the same time each day, to get the most benefit and you should not stop unless your doctor recommends it. It is important to stay on the diet and exercise program recommended by your doctor while taking this medicine. Your lifestyle plays a big part in controlling diabetes. click here : Janumet
common side effects
The most common side effects of taking Janumet 50 mg/500 mg Tablet include diarrhea, nausea, vomiting, upset stomach, headache, and sore throat. Low blood sugar level (hypoglycemia) is a possible side effect if you are also taking other diabetes medicines like insulin or sulfonylurea, so you need to know how to recognize and deal with it.
This medicine is not suitable for everyone. Before taking it, you should let your doctor know if you have ever had kidney, liver, or heart disease, problems with your pancreas, or if you drink a lot of alcohol. Pregnant or breastfeeding women should also consult their doctor before taking this medicine.
Some other medicines may affect Janumet 50 mg/500 mg Tablet so tell your doctor about all the other medicines you are taking to make sure you are safe. You should try to avoid drinking alcohol as it lowers blood glucose. Your doctor will check your kidney function and blood sugar levels before and during treatment.
Janumet 50 mg/500 mg Tablet 15’s is a combination drug of Sitagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the class of anti-diabetic. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts but it is not able to act on the organs of the body.
Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors which works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Another medicine Metformin belongs to the class of biguanides which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body’s sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.
JANUMET 50/500MG effectively reduces elevated blood glucose levels, where sitagliptin acts by increasing the release of insulin (a hormone secreted by pancreas that helps in digestion) by inhibiting the activity of an enzyme called Dipeptidyl peptidase 4 and metformin acts by blocking the production of glucose by the liver. They collectively decrease the elevated blood glucose levels and makes the body respond better to insulin.
Janumet 50 mg/500 mg Tablet 15’s should be taken with food to avoid an upset stomach. Janumet 50 mg/500 mg Tablet 15’s should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition.
The most common side effect of Janumet 50 mg/500 mg Tablet 15’s is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you.
Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, upper respiratory symptoms.
Janumet 50 mg/500 mg Tablet 15’s should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing.
If you stop taking Janumet 50 mg/500 mg Tablet 15’s abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy).
Janumet 50 mg/500 mg Tablet 15’s should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any type of heart disease, is or planning to get pregnant or breastfeeding.
Talk to your doctor if
- You have a skin blister after taking Janumet 50/500 mg tablet.
- You have a fever, vomiting, loose motion, heat exposure, less fluid intake.
- You have vomiting, pain in the stomach, breathing difficulty, tiredness, muscle cramps, decrease body temperature, decrease heartbeat after taking this medicine.
- You have low blood sugar after taking other anti-diabetic medicines along with this medicine.
- You have type 1 diabetes mellitus.
- You are undergoing any surgery.
- You have increase triglyceride levels in your blood and you have gall stones.
Directions for Use of Janumet 50/500mg Tablet 14’S
- Janumet tablet should be taken as directed by your doctor.
- Swallow it whole with a glass of water, with food. Do not cut, break or chew the medicine.
- It would be best if you took it at a fixed time for optimal results.
- You should not consume it more than that prescribed by your doctor.
- Do not stop taking Janumet 50/500 mg tablet on your own without informing your doctor.
Janumet 50 mg/500 mg Tablet 15’s helps your pancreas to produce more insulin, make effective utilization of insulin, and decreases excess of sugar that your liver makes. It helps in controlling rise of blood sugar level in your body after meal. Besides this, it does not cause weight gain in the prolonged use. Janumet 50 mg/500 mg Tablet 15’s plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.
Directions for Use
Janumet 50 mg/500 mg Tablet 15’s should not be used unless prescribed by a doctor. Always take Janumet 50 mg/500 mg Tablet 15’s exactly as your doctor told you. Your doctor will advise you how often you take your tablets on the basis of your medical condition. Swallow the tablet with a full glass of water. If required tablets can be broken in half to give a smaller dose.
Store in a cool and dry place away from sunlight
Side Effects of Janumet 50 mg/500 mg Tablet 15’s
Every medicine has some sort of side effects. In the beginning days of the treatment with Janumet 50 mg/500 mg Tablet 15’s, you may suffer from low blood sugar, runny nose, sore throat, upper lung infection, diarrhoea, nausea and vomiting, gas, stomach upset, indigestion, general weakness, and headache when used in combination with other anti-diabetic agents like sulfonylurea or insulin. But these would be temporary and may be relieved after some time. However, if you still have discomfort speak with the doctor. Lactic acidosis (excess level of lactic acid in the blood) is a rare side effect which is serious and can lead to a life-threatening condition.
In-Depth Precautions and Warning
Janumet 50 mg/500 mg Tablet 15’s should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients while taking Janumet 50 mg/500 mg Tablet 15’s might develop a rare but serious condition called lactic acidosis.
In this condition, there is too much lactic acid accumulated in the blood that can damage the working of your liver and kidney required for the elimination of excess lactic acid from the blood. Before you start taking Janumet 50 mg/500 mg Tablet 15’s, tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 level.
Janumet 50 mg/500 mg Tablet 15’s, when used with insulin, may extremely lower the blood sugar level leading to hypoglycaemia condition which can be fatal. In this case, your doctor may adjust the dose by lowering the dose of insulin or Janumet 50 mg/500 mg Tablet 15’s.
Prolonged intake of Janumet 50 mg/500 mg Tablet 15’s may lower your thyroid-stimulating hormone (TSH) hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention.
Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. The use of Janumet 50 mg/500 mg Tablet 15’s should be stopped for a short time before having an X-ray procedure.
HOW TO USE JANUMET TABLET
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Janumet 50 mg/500 mg Tablet is to be taken with food.
HOW JANUMET TABLET WORKS
Janumet 50 mg/500 mg Tablet is a combination of two antidiabetic medicines: Sitagliptin and Metformin. They help your pancreas produce more insulin, facilitate effective use of insulin by the body, and reduce excess sugar that your liver makes. Together, they provide better control of blood sugar.
WHAT IF YOU FORGET TO TAKE JANUMET TABLET?
If you miss a dose of Janumet 50 mg/500 mg Tablet, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Drug-Drug Interaction : Janumet 50 mg/500 mg Tablet 15’s interacts with an anti-depressant (bupropion), drugs used to treat glaucoma, antibiotics (cephalexin, ciprofloxacin), anti-acidity drugs (cimetidine), heart condition drugs (digoxin), anti-HIV drugs (dolutegravir), ethanol, saliva reducing drugs (glycopyrrolate), iodinated X-ray contrast agents, anti-epileptic drugs (topiramate, lamotrigine), heart-related chest medicine (ranolazine). Other drug interactions can contribute to an increased low blood sugar including sex hormones (androgens), anti-oxidant (alpha-lipoic acid), pain killers (aspirin), anti TB drugs (prothionamide), growth hormones (pegvisomant), and other antidiabetic medicines.
Drug-Food Interaction : Intake of excessive alcoholic beverages may increase the chance of life-threatening condition known as Lactic Acidosis. So, avoid intake of alcoholic beverages with Janumet 50 mg/500 mg Tablet 15’s.
Drug-Disease Interaction : People affected with heart diseases (like congestive heart failure and myocardial infarction), Vitamin B12 deficiency, and alcoholism should avoid intake of Janumet 50 mg/500 mg Tablet 15’s.
Diet & Lifestyle Advise
- Fill your half plate with starchy veggies, a quarter with proteins, and a quarter with whole grain.
- Eat at regular intervals. Do not take a long gap between a meal or snack.
- Monitor your blood sugar level regularly especially when there are lots of fluctuations.
- Invest at least 150 min of moderate-intensity physical activity or one hour and 15 minutes of high-intensity exercise every week.
- Lose weight gradually to achieve a healthy body mass index (18.5 to 24.9).
- Replace refined carbohydrates containing foods with whole grain foods and increase the intake of fruits and veggies and other fibre-enriched foods.
- Reduce intake of saturated fat (or hidden fats) in food like chips, crisps, pastries, biscuits, and samosas. Choose omega 3 fatty acid-containing oils for daily cooking. For frying, you can use palm oil, mustard oil, groundnut oil, rice bran oil, and safflower oil.
- Do not take stress as it may elevate your blood sugar level. You can adopt stress management techniques like mindfulness to control stress-related blood sugar changes.
- Opt for low-fat dairy products (low-fat yoghurt, fat-free milk, and cheese, etc.).
- Keep your blood pressure as normal (140/90) as possible. As it reduces the risk of cardiovascular diseases in diabetes patients.
It is best to avoid alcohol while taking medication.
Please consult your doctor for advice before using Janumet 50 mg/500 mg Tablet 15’s
Please consult your doctor for advice before using Janumet 50 mg/500 mg Tablet 15’s
Drive only if you are physically stable and mentally focussed, If you experience drowsiness after taking these medications you should not drive or operate any machinery or vehicles.
If u have or had history or evidence of any liver-related diseases, please consult the doctor before taking the medicine.
If u have or had history or evidence of any kidney-related diseases, please consult the doctor before taking the medicine.
Q. What is Janumet 50 mg/500 mg Tablet?
Janumet 50 mg/500 mg Tablet is a combination of two medicines: Sitagliptin and Metformin. This medicine is used in the treatment of type 2 diabetes mellitus. It improves blood glucose levels in adults when taken along with proper diet and regular exercise. Metformin works by lowering the glucose production in the liver and improving insulin sensitivity. Sitagliptin inhibits the enzyme DPP4 and increases the release of insulin from the pancreas. This combination is not indicated for the patients below 18 years of age.
Q. Can the use of Janumet 50 mg/500 mg Tablet lead to Vitamin B12 deficiency?
Yes, the use of Janumet 50 mg/500 mg Tablet can cause Vitamin B12 deficiency on long-term use. It interferes with the absorption of Vitamin B12 in the stomach. If untreated, it may cause anemia and nerve problems as a result of which the patient can feel tingling sensation and numbness in hands and feet, weakness, urinary problems, change in mental status and difficulty in maintaining balance (ataxia). To avoid such problems, some researchers suggest an intake of vitamin B12 from outside sources at least once every year.
Q. What are the possible side effects of Janumet 50 mg/500 mg Tablet?
The use of Janumet 50 mg/500 mg Tablet is associated with common side effects like hypoglycemia (low blood sugar level), altered taste, nausea, stomach pain, diarrhea, headache and upper respiratory tract infection. Its use can also lead to serious but rare side effect like lactic acidosis. On long-term use it can also lead to Vitamin B12 deficiency.
Q. Are there any specific conditions in which Janumet 50 mg/500 mg Tablet should not to be taken?
The use of Janumet 50 mg/500 mg Tablet should be avoided in patients with known allergy to any of the components or excipients of this medicine. The use of this medicine should be avoided in patients with severe kidney impairment, liver impairment, congestive heart failure, lactic acidosis or diabetic ketoacidosis.
Q. Is it safe to take alcohol while I am taking Janumet 50 mg/500 mg Tablet?
No, it is not safe to alcohol along with Janumet 50 mg/500 mg Tablet, as it can increase the chances of lactic acidosis.
Q. What are the instructions for storage and disposal of Janumet 50 mg/500 mg Tablet?
Keep this medicine in the container or the pack it came in, tightly closed. Store it according to the instructions mentioned on the pack or label. Dispose of the unused medicine. Make sure it is not consumed by pets, children and other people.
Q. Can the use of Janumet 50 mg/500 mg Tablet lead to lactic acidosis?
Yes, the use of Janumet 50 mg/500 mg Tablet can lead to lactic acidosis. It is a medical emergency which is caused by the increased levels of lactic acid in the blood. It is also known as MALA (Metformin associated lactic acidosis). It is a rare side effect associated with the use of metformin and therefore, it is avoided in patients with underlying kidney disease, old age patients or who take large amounts of alcohol.
Symptoms of lactic acidosis may include muscle pain or weakness, dizziness, tiredness, feeling of cold in arms and legs, difficulty in breathing, nausea, vomiting, stomach pain or slow heart rate. If you have these symptoms, stop taking Sitagliptin + Metformin and immediately consult your doctor.